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4T1-RLuc and 4T1BR5-FLuc cells were transduced with a lentiviral vector co-expressing the therapeutic prodrug converting fusion enzyme cytosine deaminase-uracil phosphoribosyltransferase (CD:UPRT) and tdTomato (tdT), and sorted via tdT to obtain 4T1-RLuc/CD (A) and 4T1BR5-FLuc/CD cells (C). After 72 h of incubation with 5'FC, CD expressing cells showed significantly less survival than cells without drug (B-D).
