Figure 4.

Experimental timeline for visualizing self-homing theranostic CTCs (n=15) (A). On day 6 (prior to drug administration), mice receiving 4T1BR5-CD cells had MFP RLuc signal that was not significantly different than mice receiving 4T1BR5 cells or 4T1 cells only (B). By day 19, mice receiving only 4T1-RLuc cells had significantly higher RLuc signal in the MFP compared to mice that received 4T1BR5-CD cells (C). On day 14, there was not a significant difference observed in FLuc signal between mice that received 4T1BR5-CD cells or 4T1BR5 cells (D). At endpoint, primary tumor burden measured by calipers was significantly higher in mice that received only 4T1 cells compared to mice that received 4T1BR5-CD cells (E).