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. 2020 Jun 18;10(17):7671–7682. doi: 10.7150/thno.45079

Figure 4.

Figure 4

(A) Huh7 cell viabilities of ZSZI and ZSZIT nanoparticles without NIR irradiation. (B) Huh7 cell viabilities of ZSZI, ZSZIT and ZSZIT (pH = 6.0) under normoxia condition (80 µg/mL). (C) Huh7 cell viabilities of ZSZI, ZSZIT and ZSZIT (pH = 6.0) under hypoxia condition (80 µg/mL). (D) The fluorescence images of Huh7 cells cultured with different conditions (Blank control, ZSZIT + Dark, ZSZIT + NIR and ZSZIT + NIR under hypoxia) by DCFH-DA staining for ROS detection (80 µg/mL). (E) H2S detection within Huh7 cells after culturing with ZSZIT under normal and acidic conditions (80 µg/mL). (F) The fluorescence images of intracellular O2 in Huh7 cells incubated with PBS, ZSZIT in dark, with NIR irradiation, acidic condition in dark and with NIR irradiation (80 µg/mL). (G) Schematic diagram of mechanism of ZSZIT as H2S-sensitized PDT/chemotherapeutic synergistic therapeutic nanoplatform.