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The proposed model for the K7 acetylation of Rab22a-NeoF1. Acetylation of Rab22a-NeoF1 at K7, which is acetylated by p300/CBP and deacetylated by both SIRT1 and HDAC6, may be required for its association with SmgGDS607, resulting in more RhoA-GTPase to promote lung metastasis. C646 or salicylate targeting p300/CBP may be benefit for the osteosarcoma patients who are positive for Rab22a-NeoF1.
