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Schematic of our mechanistic model. Schematic model illustrating the therapeutic effect of melatonin in a neonatal mouse model of necrotizing enterocolitis. The therapeutic effect of melatonin is Th17/Treg balance-dependent. Melatonin blocks Th17 cell- and promotes Treg cell-differentiation. Melatonin augments AMPK/SIRT1 signaling to promote Treg cell-differentiation.
