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. 2020 Jun 19;10(17):7710–7729. doi: 10.7150/thno.45858

Figure 7.

Figure 7

F-AgÅPs alter the glycolytic phenotype and depolarize mitochondria in osteosarcoma cells, but not healthy cells. (A and B) The levels of pyruvate (A) and lactic acid (B) in culture media of 143B and SJSA-1 treated with solvent or 4 ng/µL F-AgÅPs for 3 h, 6 h, 12 h or 24 h. n = 3 per group. (C) The levels of cellular ATP in 143B and SJSA-1 receiving different treatments for 3 h, 6 h, 12 h or 24 h. n = 3 per group. (D) Representative JC-1staining images of 143B and SJSA-1 receiving different treatments for 24 h. Scale bar: 50 µm. (E-G) The levels of pyruvate (E) and lactate acid (F) in culture media and ATP in supernatants of cell lysates (G) from VMSCs and HMECs treated with solvent or 4 ng/µL F-AgÅPs for 3 h, 6 h, 12 h or 24 h. n = 3 per group. (H) Representative JC-1staining images of VMSCs and HMECs receiving different treatments for 24 h. Scale bar: 50 µm. Data are shown as mean ± SD. *P < 0.05, **P < 0.01, ***P < 0.001.