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. 2020 Jul 7;7(7):1225–1239. doi: 10.1002/acn3.51109

Figure 3.

Figure 3

(A) Heat map denoting significant analytes from ADNI and Discovery datasets in the plasma from the subgroup synergistic analysis correlated to cognitive change (CDR‐SB or MMSE) for 9,12,15,24, and 36 months. Red: positive correlation, Blue: negative correlation, Magenta: has representation in both positive and negative correlation network of analytes. 3B: Abundance of Gene Ontology (GO) terms related to biological processes that enrich for key shared analytes between ADNI and Discovery datasets in the plasma in relation to cognitive change. Analytes chosen for their consistency of response included: A2M, APOA1, BDNF, CXCL8, F7, MMP2, and vWF. GO term most representative of each cluster is noted.