Table 1.
Demographics of Discovery and ADNI cohorts.
| Discovery (N = 48) | ADNI ( N = 134) | P‐value | |||
|---|---|---|---|---|---|
| N | Statistics | N | Statistics | ||
| Age at enrollment | 48 | 68.1 ± 7.3 | 134 | 74.9 ± 7.2 | <0.001a1 |
| Gender | 48 | 134 | 0.23c | ||
| Male | 28 (58.3) | 91 (67.9) | |||
| Female | 20 (41.7) | 43 (32.1) | |||
| Years of education | 48 | 16.0 [12.5, 18.0] | 134 | 16.0 [14.0, 18.0] | 0.27b |
| APOE ε4positive | 48 | 37 (77.1) | 134 | 72 (53.7) | 0.005c |
| MMSE ‐ baseline | 48 | 24.8 ± 3.1 | 134 | 26.9 ± 1.8 | <0.001a2 |
| CDR‐SB ‐ baseline | 48 | 2.1 ± 1.2 | 134 | 1.5 ± 0.89 | 0.002a2 |
| CSF AB42, pg/mL | 48 | 305.9 [216.1, 367.1] | 134 | 144.5 [129.0, 171.0] | |
| CSF t‐tau, pg/mL | 48 | 454.3 [335.2, 771.3] | 134 | 90.6 [67.8, 134.0] | |
| CSF p‐tau, pg/mL | 48 | 79.6 [59.3, 104.6] | 134 | 35.7 [23.0, 45.8] | |
Statistics presented as Mean ± SD, Median [P25, P75], N (column%).
P‐values: a1 = t‐test, a2 = Satterthwaite t‐test, b = Wilcoxon Rank Sum test, c = Pearson's chi‐square test, d = Fisher's Exact test.
P‐value < 0.05 is noted in bold.
CDR‐SB, Clinical dementia rating scale‐sum of boxes; MMSE, Mini mental state exam.