Table 4.

Plasma biomarkers of CDR‐SB and MMSE change are shown for both cohorts at specified time points, after adjustment for age, sex, APOE status and education.

Time	CDR‐SB Change			MMSE Change
	Factor	Estimate (95% CI)	P‐value	Factor	Estimate (95% CI)	P‐value
Discovery cohort
9 months	CXCL8	0.37 (−0.39, 1.12)	0.33	A2M	−4.24 (−7.67, −0.81)	0.017
	F7	−1.19 (−2.04, −0.34)	0.007	F7	−1.97 (−3.81, −0.13)	0.037
	MMP2	−0.70 (−1.80, 0.41)	0.21	BDNF	0.28 (−0.23, 0.79)	0.27
15 months	CXCL8	1.75 (0.66, 2.84)	0.003	A2M	−4.37 (−8.62, −0.12)	0.044
	APOA1	−1.41 (−3.75, 0.93)	0.23	F7	−1.83 (−4.26, 0.60)	0.13
	F7	−0.85 (−2.14, 0.44)	0.19	MMP2	−1.28(−4.47, 1.92)	0.42
ADNI Cohort
12 months	A2M	0.66 (0.06, 1.27)	0.032	CXCL8	1.03 (0.34, 1.71)	0.004
	APOA1	0.28 (−0.13, 0.69)	0.18	APOA1	−0.61 (−1.50, 0.28)	0.18
				BDNF	−0.24 (−0.63, 0.15)	0.23
24 months	APOA1	0.57 (−0.08, 1.23)	0.086	APOA1	−1.16 (−2.35, 0.03)	0.057
	BDNF	0.23 (−0.05, 0.51)	0.10	MMP2	1.48 (0.88, 2.08)	< 0.001
	MMP2	−0.56 (−0.89, −0.22)	0.001
36 months	A2M	1.73 (−0.28, 3.74)	0.090	A2M	−1.29 (−3.91, 1.33)	0.33
	MMP2	1.12 (−0.19, 2.42)	0.093	APOA1	−1.26 (−3.13, 0.61)	0.18

P‐value < 0.05 is noted in bold.