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Regulation of Actin Cytoskeleton is significantly downregulated in SMA type 3 patients. KEGG pathway modified to highlight the genes in Regulation of Actin Cytoskeleton pathways that were significantly downregulated in the L1000 experiment (blue). Additional key genes in this pathway were highlighted (green) for further testing using RT‐qPCR. Of note, CRK, PAK6, PXN, and RHOA are included in the list of 978 "landmark" genes
