Fig. 1.

¹⁸F-DOPA uptake in putamen and ipsilateral ¹¹C-PK11195 binding in substantia nigra in non-manifesting LRRK2 G2019S carriers. Values from left and right side in eight non-manifesting LRRK2 G2019S carriers are depicted. ⨂ indicates significantly reduced ¹⁸F-DOPA Ki values, which are two or more standard deviations below the average mean of controls (z score ≤ − 2). Red colour indicates significantly raised ¹¹C-PK11195 BP_ND two or more standard deviations above the average mean of controls (z score ≥ 2). Observations from each individual carrier are marked with numbers from one to eight, which corresponds to their number in Table 1, individual analysis