Table 1.
11C-PK11195 BPnd and 18F-DOPA Ki in controls and non-manifesting LRRK2 carriers
| 11C-PK11195 BPnd | 18F-DOPA Ki | |||
|---|---|---|---|---|
| Controls (n = 20) | LRRK2-NMCs (n = 8) | Controls (n = 9) | LRRK2-NMCs (n = 8) | |
| Group analysis | ||||
| Substantia nigra | − 0.006 (0.09) | 0.08 (0.16) | – | – |
| Putamen | 0.08 (0.11) | 0.06 (0.13) | 0.0131 (0.00069) | 0.0120* (0.00087) |
| Caudate | − 0.15 (0.12) | − 0.17 (0.13) | 0.0113 (0.00085) | 0.0120 (0.0017) |
|
Reduced putamen 18F-DOPA Ki |
Raised substantia nigra 11C-PK11195 BPnd |
Raised putamen 11C-PK11195 BPnd |
UPDRS-III | MMSE | |
|---|---|---|---|---|---|
| Individual analysis | |||||
| Carrier 1 | 0 | 28 | |||
| Carrier 2 | 5 | 30 | |||
| Carrier 3 | ○ | ● | 4 | 30 | |
| Carrier 4 | ○ | 3 | 30 | ||
| Carrier 5 | ○ | 2 | 29 | ||
| Carrier 6 | 3 | 30 | |||
| Carrier 7 | ● | ● | 3 | 29 | |
| Carrier 8 | ○ | ● | ○ | 1 | 26 |
Values from both left and right side are averaged in the group analysis. Values are mean and standard deviation in brackets. *p < 0.05 in group analysis
Unilateral (○) or bilateral (●) reduced putaminal 18F-DOPA Ki value (z score ≤ − 2) and/or raised substantia nigra 11C-PK11195 BPND (z score ≥ 2) in individual carriers
NMCs non-manifesting carriers, UPDRS-III Unified Parkinson’s Disease Rating Scale—part three, MMSE Mini-Mental State Examination