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. 2020 Jun 24;40(8):755–764. doi: 10.1007/s40261-020-00936-0

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License, which permits any non-commercial use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by-nc/4.0/.

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Fig. 1 — Primary treatment response from controlled phase III trials. The primary endpoint analysis compared the percentage of treatment responders in each oliceridine regimen with the percentage of responders in the placebo regimen. a Hard tissue (bunionectomy) study and b soft tissue (abdominoplasty) study. The duration in the hard tissue (bunionectomy) study was 48 h and in the soft tissue (abdominoplasty) study was 24 h. A patient was considered a treatment responder if all the following conditions were met: at least a 30% improvement in their final time-weighted sum of pain intensity difference (SPID) from baseline at 48 h (for bunionectomy) or 24 h (for abdominoplasty); without rescue pain medication during the randomized treatment period; without early discontinuation of study medication for any reason; without reaching the study medication dosing limit. *P vs. placebo (Hochberg adjusted), CI confidence interval