Table 6.
Patient distribution as per MIDAS grades, from baseline (T0) up to 48 months (T48) at 6-month time intervals
|
T0 (n = 109) |
T6 (n = 101) |
T12 (n = 84) |
T18 (n = 50) |
T24 (n = 38) |
T30 (n = 33) |
T36 (n = 27) |
T42 (n = 22) |
T48 (n = 22) |
||
| MIDAS–n (%) | n | 109 | 101 | 84 | 50 | 38 | 33 | 27 | 22 | 22 |
| Grade I | 0 (0.0) | 36 (35.6) | 36 (42.9) | 28 (56.0) | 17 (44.7) | 23 (69.7) | 15 (55.6) | 12 (54.5) | 12 (54.5) | |
| Grade II | 0 (0.0) | 25 (24.8) | 22 (26.2) | 15 (30.0) | 14 (36.8) | 7 (21.2) | 8 (29.6) | 9 (40.9) | 9 (40.9) | |
| Grade III | 35 (32.1) | 26 (25.7) | 21 (25.0) | 6 (12.0) | 5 (13.2) | 3 (9.1) | 4 (14.8) | 1 (4.5) | 1 (4.5) | |
| Grade IV | 74 (67.9) | 14 (13.9) | 5 (6.0) | 1 (2.0) | 2 (5.3) | 0 (0.0) | 0 (0.0) | 0 (0.0) | 0 (0.0) | |
| p values from HGLM and pairwise comparisons* | ||||||||||
| p for overall difference | T6 vs T0 | T12 vs T6 | T18 vs T12 | T24 vs T18 | T30 vs T24 | T36 vs T30 | T42 vs T36 | T48 vs T42 | p for linear trend | |
| MIDAS I | 0.002 | 0.085 | 0.586 | 0.085 | 0.586 | 0.085 | 0.586 | 0.990 | 0.990 | < 0.001 |
| MIDAS II | 0.182 | 0.190 | 0.966 | 0.966 | 0.966 | 0.738 | 0.966 | 0.966 | 0.966 | < 0.001 |
| MIDAS III | 0.035 | 0.970 | 0.970 | 0.181 | 0.970 | 0.970 | 0.970 | 0.970 | 0.970 | < 0.001 |
| MIDAS IV | < 0.001 | < 0.001 | 0.083 | 0.358 | 0.358 | 1.000 | 1.000 | 1.000 | 1.000 | < 0.001 |
*p values from hierarchical generalised linear model (HGLM) and adjusted following Hochberg’s step-up procedure