Table 7.

Shift from baseline to worst postbaseline anxiety severity on GAD-7

Treatment	Baseline category		Worst postbaseline category
	n (%)		None	Mild	Moderate	Severe	Missing
			n (%)	n (%)	n (%)	n (%)	n (%)
Buparlisib (80 mg)+ carboplatin (n=3)	None	3 (100)	2 (66.7)	1 (33.3)	0	0	0
	Mild	0	0	0	0	0	0
	Moderate	0	0	0	0	0	0
	Severe	0	0	0	0	0	0
	Total	3 (100)	2 (66.7)	1 (33.3)	0	0	0
Buparlisib (100 mg)+ carboplatin (n=14)	None	11 (78.6)	5 (45.5)	4 (36.4)	1 (9.1)	1 (9.1)	0
	Mild	3 (21.4)	1 (33.3)	1 (33.3)	1 (33.3)	0	0
	Moderate	0	0	0	0	0	0
	Severe	0	0	0	0	0	0
	Total	14 (100)	6 (42.9)	5 (35.7)	2 (14.3)	1 (7.1)	0
Buparlisib (60 mg)+ lomustine (n=18)	None	12 (66.7)	5 (41.7)	5 (41.7)	1 (8.3)	0	1 (8.3)
	Mild	5 (27.8)	3 (60.0)	2 (40.0)	0	0	0
	Moderate	0	0	0	0	0	0
	Severe	1 (5.6)	0	1 (100)	0	0	0
	Total	18 (100)	8 (44.4)	8 (44.4)	1 (5.6)	0	1 (5.6)

Grades based on severity: normal (severity: none, score: 0–4), mild (score: 5–9)

GAD-7, Generalized Anxiety Disorder-7.