Table 2.
CBF in different brain regions among the PD, PPS, and HC groups
| Peak location (AAL-90) | MNI coordinate | No. of voxels | Peak F-value |
HC | PD | PPS | PD-HC | PPS-HC | PPS-PD | ||
|---|---|---|---|---|---|---|---|---|---|---|---|
| x | y | z | Mean/SD | Mean/SD | Mean/SD | p-value | p-value | p-value | |||
| SMA.L | − 2 | 24 | 60 | 481 | 3.73 | 43.54/11.98 | 42.59/10.87 | 29.04/10.15 | 0.794 | < 0.001 | 0.001 |
| THA.R | 1 | −16 | 5 | 313 | 3.74 | 58.83/12.32 | 54.01/11.62 | 42.38/12.21 | 0.229 | < 0.001 | 0.006 |
| FG_Med_Orb.L | 0 | 64 | −4 | 646 | 3.82 | 57.03/11.38 | 47.94/12.05 | 40.56/9.34 | 0.016 | < 0.001 | 0.053 |
| IFG_Tri.L | −52 | 20 | 2 | 580 | 3.88 | 46.62/4.65 | 41.28/9.29 | 35.15/7.07 | 0.034 | < 0.001 | 0.017 |
| MFG.L | −40 | 26 | 40 | 377 | 3.93 | 48.80/7.25 | 41.58/11.46 | 33.62/9.67 | 0.029 | < 0.001 | 0.018 |
| Cere_Crus2.R | 50 | −66 | −50 | 622 | 4.25 | 31.52/10.35 | 19.45/13.53 | 14.58/6.15 | 0.001 | < 0.001 | 0.182 |
| CN. L | −10 | 4 | 12 | 457 | 4.56 | 33.61/5.34 | 29.48/4.19 | 24.93/6.11 | 0.020 | < 0.001 | 0.012 |
Abbreviations: CBF, cerebral blood flow; AAL, automated anatomical labeling; HC, healthy controls; PD, Parkinson’s disease; PPS, Parkinsonism-Plus syndrome; SMA, supplementary motor area; THA, thalamus; FG_Med_Orb, frontal medial orbital gyrus; IFG_Tri, triangle inferior frontal gyrus; MFG, middle frontal gyrus; Cere_Crus2, cerebellum_crus2; CN, caudate nucleus; L (R), left (right) hemisphere; SD, standard deviation