Table 1.
Set of 58 genes selected for targeted analysis.
| Enzyme | Gene | Previous association with ADHD (ref.) |
|---|---|---|
| Serine-palmitoyl transferase | SPTLC1 | Association/trend with gene-related region62,67 |
| SPTLC2 | ||
| SPTLC3 | Association/trend with gene-related region62,67 | |
| SPTSSA | ||
| SPTSSB | Association with gene-related CNV69 | |
| 3-Ketodihydrosphingosine reductase | KDSR | |
| Ceramide synthase | CERS1 | |
| CERS2 | ||
| CERS3 | ||
| CERS4 | ||
| CERS5 | ||
| CERS6 | ||
| Dihydroceramide desaturase | DEGS1 | |
| DEGS2 | ||
| Fatty acid elongases | ELOVL1 | |
| ELOVL2 | ||
| ELOVL3 | ||
| ELOVL4 | ||
| ELOVL5 | ||
| ELOVL6 | Trend associated SNP66 | |
| ELOVL7 | Gene-related CNV65 | |
| Ceramide kinase | CERK | |
| Sphingomyelin synthase | SMS1 | |
| SMS2 | ||
| Sphingomyelinase | SMPD1 | Gene-related CNV69 |
| SMPD2 | ||
| SMPD3 | ||
| SMPD4 | Association with gene-related region68 | |
| SMPDL3A | Association with gene-related region67 | |
| SMPDL3B | ||
| ENPP7 | ||
| UDP-glucose ceramide glucosyltransferase | UGCG | Association with gene-related region67 |
| UDP-galactosyltransferase 8 | UGT8 | |
| Galactosylceramidase | GALC | |
| Beta-1-4-galactosyltransferase 6 | B4GALT6 | Association with gene-related region67 |
| Galactose-3-O-sulfotransferase | GAL3ST1 | |
| Alkaline ceramidase | ACER1 | |
| ACER2 | ||
| ACER3 | Association/trend with gene-related region12,64 | |
| Acid ceramidase | ASAH1 | |
| ASAH2 | ||
| Sphingosine kinase | SPHK1 | |
| SPHK2 | ||
| S1P-phosphatase | SGPP1 | |
| SGPP2 | ||
| S1P lyase | SGPL1 | |
| S1P-receptor | S1PR1 | |
| S1PR2 | ||
| S1PR3 | Association/trend with gene-related region62,67 | |
| S1PR4 | ||
| S1PR5 | ||
| Fatty acid desaturase | FADS1 | |
| FADS2 | Association with SNPs in the gene15,63,66 | |
| FADS3 | Association/trend with gene-related region64,107 | |
| N-SMase activation associated factor | NSMAF | |
| Ceramide transfer protein | COL4A3BP |