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. 2020 Jul 13;11(7):530. doi: 10.1038/s41419-020-2719-2

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — Tumour formation assays in nude mice subcutaneously injected with MDA-MB-231/DR or MDA-MB-231/VR cells. When the tumours reached ~100 mm³, the mice were divided into a control group and groups receiving docetaxel (Doc, 8 mg/kg), aspirin (Asp, 50 mg/kg), and/or vinorelbine (Vin, 2 mg/kg). a, b The survival of mice was analysed by Kaplan–Meier analysis. c, d The tumour sizes were measured, and the inhibition rates were calculated. MDA-MB-231/DR group (Control vs Doc, P = 0.020, Control vs Doc + Asp, P < 0.001). MDA-MB-231/VR group (Control vs Vin, P = 0.030, Control vs Vin + Asp, P < 0.001). e, f Representative immunohistochemical staining results for Ki67, YAP and β-catenin in xenograft tumour tissues. The graph shows the immunoreactivity scores of Ki67, YAP and β-catenin in each group. Scale bar: 25 µM. In MDA-MB-231/DR group, the P values were shown, as fellow: Ki67 (Control vs Doc, P < 0.001; Control vs Doc + Asp, P < 0.001), YAP (Control vs Doc, P = 0.009; Control vs Doc+Asp, P < 0.001), β-catenin (Control vs Doc, P < 0.001; Control vs Doc+Asp, P < 0.001). In MDA-MB-231/VR group, the P values were shown, as fellow: Ki67 (Control vs Doc, P < 0.001; Control vs Doc + Asp, P < 0.001), YAP (Control vs Doc, P = 0.002; Control vs Doc+Asp, P < 0.001), β-catenin (Control vs Doc, P = 0.004; Control vs Doc+Asp, P < 0.001). The data are presented as the mean ± SD of experiments performed. Statistical significance was determined using Student’s t test and log-rank analysis.