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. 2020 Jul 13;11(7):526. doi: 10.1038/s41419-020-02745-x

Fig. 6. Circ-ADAM9 targets PTEN/AKT/mTOR and ATG7 to regulate autophagy and apoptosis of EPCs under high-glucose condition.

Fig. 6

a Western blot analysis of PTEN and ATG7 protein levels in EPCs under high-glucose condition upon overexpression and knockdown of circ-ADAM9. b Western blot analysis of BCL-2, BAX, and cleaved-CASP3 protein levels in cells transfected with si-PTEN/si-ATG7 and LV-circ-ADAM9. c Western blot analysis of LC3B-II/LC3B-II and SQSTM1/p62 levels in cells transfected with si-PTEN/si-ATG7 and LV-circ-ADAM9. d Western blot analysis of p-AKT and p-mTOR levels after transfection with si-PTEN and LV-circ-ADAM9. e Western blot analysis of p-AKT and p-mTOR levels after transfection with 3-MA and LV-circ-ADAM9. *P < 0.05; **P < 0.01; n = 3.