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. 2020 Jul 13;11(7):526. doi: 10.1038/s41419-020-02745-x

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 7 — a Non-diabetic and diabetic nude mice with hind limb ischemia were injected with human umbilical vein EPCs transfected with lentivirus sh-circ-ADAM9or sh-NC. Blood flow in hind limbs was measured using a laser Doppler imaging system on days 0, 4, 7, and 14 after injection. Representative images and blood flow ratios are shown. b CD31-specific immunofluorescence staining (red) in ischemic muscle tissues of nude mice 14 days after injection of the cells. c Western blot analysis of BCL-2, BAX, cleaved-CASP3, LC3B-II/LC3B-II, and SQSTM1/p62 levels. d Circ-ADAM9 promotes the expression of PTEN and decreases the phosphorylation of AKT/mTOR, and circ-ADAM9 directly induces the expression of the autophagy-related gene ATG7, leading to the enhancement of autophagy and apoptosis of EPCs in diabetes. *P < 0.05, **P < 0.01; n = 6.