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. 2020 Jul 13;10:11521. doi: 10.1038/s41598-020-67876-9

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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I/R-induced changes of HAS1 expression in the rat small intestine myenteric plexus (A–I) Confocal images showing co-localization of HAS1 with the pan neuronal marker HuC/D in myenteric neurons of CTR animals (A–C), after I/R injury (D–F) and in the 4-MU-treated I/R group (G–I). HAS1 stained the soma and cytoplasmic membranes of ovoid myenteric neurons, interconnecting fibers (*) and enteric glial cells (arrow). Panel J shows the percentage of myenteric neurons co-staining for HuC/D and HAS1. Bar 50 μm. **P < 0.01, ***P < 0.001 vs. CTR, ^###P < 0.001 vs. sham-operated by one-way ANOVA with Tukey’s post hoc test. N = 5 rat/group (K) HAS1 mRNA levels in LMMP preparations obtained from the different experimental groups. Histograms show HAS1 relative gene expression determined by comparing 2^−ΔΔCt values normalized to β-actin. *P < 0.05, **P < 0.01, ***P < 0.001 vs. CTR, ^###P < 0.001 vs. sham-operated by one-way ANOVA with Tukey’s post hoc test. N = 5 rat/group.