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. 2020 Jul 13;10:11521. doi: 10.1038/s41598-020-67876-9

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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4-MU treatment affects G/I transit and gastric emptying after I/R injury in the rat. (A) Percentage of non-absorbable FITC-dextran 250 distribution along the gastrointestinal (GI) consisting of stomach (Sto), small bowel (Sb 1–10), caecum (Cec) and colon (C 1–3); (B) geometric centre (GC) of non-absorbable FITC-dextran distribution; (C) Percentage of gastric emptying in the different experimental groups. Data are reported as mean ± SEM for panels (A) and (C) and as median, minimum, maximum, upper and lower quartiles for panel (B). **P < 0.01 and ***P < 0.001 vs. CTR, ^##P < 0.01 and ^###P < 0.001 vs. sham-operated, ^§P < 0.05 vs. I/R, by one-way ANOVA with Tukey’s post hoc test (panel C). N = 5 rat/group.