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. 2020 Jul 13;11:3492. doi: 10.1038/s41467-020-17270-w

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — a Experimental design, bilateral vCA1 optogenetic activation of vGAT-Chrimson cells with 532 nm laser. Left: DIO-Chrimson or DIO-mCherry was injected into vCA1 of vGAT-Cre mice bilaterally and fiber optics implanted. Right: Example image of vCA1 with expression of Chrimson, and fiber optic targeting. The main effect of this experiment was replicated in an independent dataset within the lab. b Left: Experimental design, laser stimulation was delivered for 6 s during the footshock in A1 context encoding (ON 178–184 s). Right: Bilateral vCA1 shock silencing with vGAT-Chrimson stimulation during context encoding significantly reduced % time freezing during context retrieval relative to vGAT-mCherry control mice (repeated-measures ANOVA; % time freezing*genotype interaction F_(1,15) = 6.26, *p = 0.0244, Chrimson N = 8, mCherry N = 9). Error bars, ±s.e.m. Statistical tests comparing distributions were two-sided. Source data are provided as a Source Data file.