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. Author manuscript; available in PMC: 2020 Jul 14.
Published in final edited form as: Mov Disord. 2020 Feb 10;35(5):868–876. doi: 10.1002/mds.27998

Figure 2.

Figure 2.

Junction sequences of SNCA duplication cases. Nucleotide positions from chromosome 4 (GCRh37/hg19) are indicated. Original sequence of the distal breakpoint, junction sequence, and original sequence of the proximal breakpoint are represented for each case. Sequences downstream of the distal breakpoint or upstream of the proximal breakpoint are indicated in gray. Short stretch of microhomology is shown in red, and nucleotide insertions at the duplication junctions are shown in blue. Homologous region found near the breakpoints are indicated with a blue box. Repetitive elements found at a distal breakpoint are indicated by a yellow box, and those on a proximal breakpoint are indicated with a red box. (A) junction sequence of Case 1, (B) junction sequence of Case 2, (C) junction sequence of Cases 3 and 6, (D) junction sequence of Case 4, (E) junction sequence of Case 5.