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. 2020 Apr 23;18(2):1559325820917829. doi: 10.1177/1559325820917829

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© The Author(s) 2020

This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).

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Figure 4. — Effect of SNORD16 knockdown on colon cancer in vitro. A, The knockdown efficiency of SNORD16 in HCT116 and SW620 cells after transfection with siNC, siRNA-1, and siRNA-2. B and C, Cell Counting Kit-8 (CCK-8) assays indicate that SNORD16 knockdown inhibits the cell proliferation in both HCT116 and SW620 cells. D, SNORD16 knockdown decreases colony formation in HCT116 and SW620. E, SNORD16 knockdown reduces the migration and invasion capacity of HCT116 cells. F, SNORD16 knockdown induces apoptosis in both HCT116 and SW620 cells. *P < .05; **P < .01; ***P < .001.