Table 1.

Overview of peptide-binding receptors studied for anti-cancer drug delivery.

Targeted receptor	Tumor expression	References
Integrin (αvβ3)	Activated endothelial cells and tumor cells (such as U87MG glioblastoma cells), ovarian cancer cells	Desgrosellier and Cheresh, 2010; Chen and Chen, 2011
EGFR	Lung, breast, bladder, and ovarian cancers	Li et al., 2005; Yarden and Pines, 2012
NPY (hY1R)	Breast cancer, Ewing sarcoma	Söll et al., 2001; Körner et al., 2008; Li et al., 2015
Bn receptors (GRPR)	Lung, prostate, breast, pancreatic, head/neck, colon, uterine, ovarian, renal cell, glioblastomas, neuroblastomas, gastrointestinal carcinoids, intestinal carcinoids, and bronchial carcinoids	Jensen et al., 2008; Sancho et al., 2011
Somatostatin (SSTR2)	Small cell lung, neuroendocrine tumor, prostate cancer, breast cancer, colorectal carcinoma, gastric cancer, hepatocellular carcinoma	Volante et al., 2008; Sun and Coy, 2011
GnHR-R	Ovarian, breast, prostate, lung cancer	Schally and Nagy, 1999; Limonta et al., 2012
VIP receptors	Endocrine tumors, colon, breast cancer	Reubi, 2003; Tang et al., 2014
MC1R	Melanoma tissues	Froidevaux and Eberle, 2002; Froidevaux et al., 2005
Neurotensin receptors (NTSR1)	Breast, colon, pancreatic, lung, prostate cancer	Kokko et al., 2003; Wu et al., 2012