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. Author manuscript; available in PMC: 2020 Oct 1.
Published in final edited form as: Radiat Res. 2020 Feb 19;193(4):305–317. doi: 10.1667/RADE-20-00013

Figure 5. KAP1 knockout inhibits metastasis and delays tumor growth conjunction with RT in syngeneic 4T1 breast cancer model.

Figure 5.

(A, B). Tumor growth (A) and Kaplan-Meier survival curves (B) of Balb/C mice inoculated with 5×105 vector control or KAP1 knockout 4T1 cells and treated with 0Gy or 8 Gy of X-rays at day 8 post inoculation.

(C). Representative images of lungs of mice inoculated vector control and KAP1 knockout 4T1 cells.

(D, E). Quantification of lung metastases by mass (D) and metastatic surface nodules (E) (n=5 per group).

Data represent two independent experiments (A and B). Error bars represent SEM. *p<0.05, **p<0.01, ***p<0.001, ns, not significant, as determined by two-way ANOVA (A), log-rank (B), or unpaired Student’s T-test (D and E)