Table 2.
Baseline characteristics of the included studies
| Groups | Dijos [16] | Bouleti [17] | Gajanana [18] | Agrawal [10] | |
|---|---|---|---|---|---|
| Demographics | |||||
| Age | C-XRT | 68.3 ± 1.7* | 73.4 (61.3–83.6) | 76 ± 13* | 81.64 ± 7.81 |
| Control | 82.5 ± 6.6 | 73.3 (67.8–83.1) | 82 ± 8 | 82.67 ± 7.98 | |
| Male sex | C-XRT | 7 (36.84) | 13 (50) | 10 (23) * | 29 (38.66) |
| Control | 101 (56.4) | 13 (50) | 583 (51) | 291 (54.39) | |
| BMI ((kg/m2) | C-XRT | 25.9 ± 5.1 | 21.9 (18.7–24.9)* | 29.1 ± 8.9 | 27.14 ± 6.32 |
| Control | 27.1 ± 5.7 | 27.9 (22.9–29.8) | 28.2 ± 8.6 | 28.11 ± 5.98 | |
| Comorbid conditions | |||||
| Hypertension | C-XRT | 9 (47.31) * | 12 (46) | 37 (86) | 66 (88) |
| Control | 139 (77.6) | 22 (85) | 1062 (93) | 476 (88.9) | |
| Diabetes mellitus | C-XRT | 1 (5.3) * | 0 (0) | 13 (31) | 31 (41.3 |
| Control | 56 (31.3) | 7 (2) | 392 (34) | 176 (32.5) | |
| Coronary Artery disease | C-XRT | 9 (47.3) | 14 (54) | 3 (7) | 50 (66.67) |
| Control | 104 (58.1) | 12 (46) | 193 (17) | 307 (57.3) | |
| Prior stroke | C-XRT | 0 (0) | 1 (4) | 4 (9) | 10 (13.33) |
| Control | 11 (6.1) | 2 (8) | 125 (12) | 53 (9.9) | |
| Risk scores and Echocardiographic characteristics | |||||
| STS score (%) | C-XRT | NR | 5.0 (2.9–6.1) | 7 ± 4 | 8.1 (5.1–11) |
| Control | 4.7 (3.0–8.7) | 8 ± 5 | 8.1 (5.3–11) | ||
| LVEF (%) | C-XRT | 57 ± 11.3 | 60 (45–60) | 53 ± 11 | 55.65 ± 12.40 |
| Control | 53.8 ± 14.8 | 60 (45–60) | 52 ± 13 | 54.46 ± 13.1 | |
| Mean AV gradient (mm Hg) | C-XRT | 47.9 ± 15.5 | 47 (41–57) | 41 ± 9* | 43.06 ± 13.67 |
| Control | 45.9 ± 15.8 | 52 (46–65) | 45 ± 13 | 40.87 ± 15.48 | |
Values presented as n (%), mean (SD), or median (25-75th percentiles)
(*) indicates p valve < 0.05 for patients in the radiation group (C-XRT) compared to the control group
BMI Body mass index, STS Surgical Thoracic Society risk score, LVEF Left ventricular ejection fraction, AV Aortic valve, NR Not reported