Table 3.
Models for COVID-19 test positivity and all-cause mortality with test-confirmed COVID-19: M3 and M4
| M3: current chronological age + diseases | M4: current chronological age + PhenoAgeAccel + diseases | |||
|---|---|---|---|---|
| Positive alive vs. untested or negative (n=418,644) | Positive dead vs. untested or negative (n=417,381) | Positive alive vs. untested or negative (n=346,055) | Positive dead vs. untested or negative (n=345,063) | |
| Sex1 (=Male) |
1.24 (1.12, 1.38) p=6.91e-5 |
2.52 (1.84, 3.45) p=9.95e-9 |
1.23 (1.09, 1.39) p=6.54e-4 |
2.28 (1.61, 3.22) p=3.42e-6 |
| Ethnicity2 | ||||
| Black |
3.05 (2.39, 3.89) p=3.62e-19 |
4.37 (2.42, 7.90) p=1.06e-6 |
3.02 (2.28,4.00) p=9.38e-15 |
4.16 (2.13, 8.12) p=2.87e-5 |
| Other (incl. Asian, Chinese, and Mixed) |
1.90 (1.54, 2.33) p=1.09e-9 |
0.88 (0.40, 1.92) p=0.747 |
1.89 (1.49, 2.39) p=1.07e-7 |
0.98 (0.42, 2.29) p=0.970 |
| Current Age (per 5 years) |
0.94 (0.91, 0.98) p=0.001 |
1.60 (1.41, 1.81) p=1.25e-13 |
0.97 (0.93, 1.01) p=0.093 |
1.61 (1.40, 1.84) p=6.31e-12 |
| PhenoAgeAccel (per 5 years) |
1.15 (1.08, 1.21) p=3.20e-6 |
1.25 (1.09, 1.44) p=0.002 |
||
| Dementia (46 pos., 13 pos. dead) |
8.56 (6.15, 11.91) p=3.89e-37 |
8.28 (4.33, 15.83) p=1.68e-10 |
8.83 (6.14, 12.69) p=6.59e-32 |
9.14 (4.58, 18.24) p=3.55e-10 |
| Type II diabetes (201 pos., 51 pos. dead) |
1.61 (1.36, 1.90) p=2.94e-8 |
2.31 (1.62, 3.30) p=4.32e-6 |
1.50 (1.24, 1.82) p=3.51e-5 |
1.94 (1.29, 2.93) p=0.001 |
| History of pneumonia (124 pos., 23 pos. dead) |
1.95 (1.60, 2.38) p=3.66e-11 |
1.72 (1.06, 2.78) p=0.028 |
1.82 (1.45, 2.28) p=1.73e-7 |
1.44 (0.83, 2.50) p=0.192 |
| Depression (174 pos., 30 pos. dead) |
1.28 (1.09, 1.52) p=0.003 |
1.90 (1.26, 2.87) p=0.002 |
1.40 (1.16, 1.67) p=3.36e-4 |
2.00 (1.28, 3.12) p=0.002 |
| Atrial fibrillation (126 pos., 28 pos. dead) |
1.61 (1.32, 1.97) p=2.95e-6 |
1.49 (0.96, 2.29) p=0.073 |
1.56 (1.25, 1.95) p=8.63e-5 |
1.41 (0.88, 2.28) p=0.153 |
| Hypertension (670 pos., 131 pos. dead) |
1.30 (1.16, 1.46) p=1.17e-5 |
1.79 (1.29, 2.48) p=5.09e-4 |
1.25 (1.00, 1.43) p=9.07e-4 |
1.84 (1.29, 2.63) p=8.64e-4 |
| COPD (110 pos., 26 pos. dead) |
1.55 (1.25, 1.93) p=5.54e-5 |
2.04 (1.29, 3.24) p=0.002 |
1.45 (1.14, 1.85) p=0.003 |
1.90 (1.14, 3.17) p=0.013 |
| Chronic kidney disease (55 pos., 9 pos. dead) |
1.93 (1.45, 2.58) p=7.06e-6 |
1.11 (0.55, 2.27) p=0.769 |
1.77 (1.28, 2.44) p=5.64e-4 |
0.83 (0.36, 1.89) p=0.657 |
| Liver disease (42 pos., 6 pos. dead) | 1.32 (0.96, 1.82) p=0.083 |
0.96 (0.41, 2.25) p=0.931 |
1.40 (0.99, 1.98) p=0.054 |
0.93 (0.36, 2.39) p=0.878 |
| Rheumatoid Arthritis (38 pos., 12 pos. dead) | 1.11 (0.80, 1.55) p=0.527 |
2.26 (1.23, 4.14) p=0.008 |
0.99 (0.68, 1.45) p=0.956 |
1.55 (0.74, 3.28) p=0.246 |
| Coronary artery disease (220 pos., 44 pos. dead) | 1.08 (0.92, 1.27) p=0.349 |
0.89 (0.61, 1.29) p=0.539 |
1.09 (0.91, 1.30) p=0.374 |
0.84 (0.56, 1.28) p=0.421 |
| History of delirium (13 pos., 5 pos. dead) | 1.34 (0.73, 2.44) p=0.341 |
1.88 (0.69, 5.14) p=0.216 |
1.30 (0.67, 2.52) p=0.443 |
2.12 (0.75, 6.02) p=0.158 |
| Stroke (46 pos., 10 pos. dead) | 1.19 (0.88, 1.62) p=0.266 |
1.09 (0.56, 2.12) p=0.790 |
1.34 (0.97, 1.85) p=0.077 |
1.29 (0.66, 2.53) p=0.454 |
| Asthma (226 pos., 26 pos. dead) | 0.96 (0.83, 1.12) p=0.607 |
0.71 (0.46, 1.11) p=0.131 |
0.96 (0.81, 1.13) p=0.611 |
0.72 (0.45, 1.16) p=0.175 |
| Previous falls/fragile fractures (387 pos., 65 pos. dead) | 1.08 (0.96, 1.22) p=0.194 |
1.35 (0.99, 1.84) p=0.061 |
1.04 (0.90, 1.19) p=0.613 |
1.20 (0.85, 1.69) p=0.311 |
| Osteoarthritis (175 pos., 35 pos. dead) | 1.02 (0.86, 1.20) p=0.859 |
1.17 (0.80, 1.71) p=0.416 |
0.97 (0.81, 1.17) p=0.759 |
1.16 (0.76, 1.76) p=0.487 |
1
reference: female
2
reference: White
in bold if p<0.05; assessment center results skipped