Table 4.

Diagnostic values when the sensitivity is controlled at 0.6, or 0.8 for test positivity or all-cause mortality with test-confirmed COVID-19

Model	AUC	Threshold	SEN	SPEC	PPV	NPV
Test positivity
M1	0.601	0.00247	0.804	0.292	0.00379	0.99775
M1	0.601	0.00320	0.602	0.550	0.00447	0.99758
M2	0.626	0.00242	0.805	0.339	0.00407	0.99808
M2	0.626	0.00321	0.603	0.581	0.00480	0.99772
M3	0.663	0.00228	0.806	0.360	0.00420	0.99820
M3	0.663	0.00308	0.606	0.641	0.00562	0.99794
M4	0.669	0.00227	0.805	0.369	0.00426	0.99824
M4	0.669	0.00314	0.603	0.652	0.00578	0.99796
All-cause mortality with test-confirmed COVID-19
M1	0.755	0.00029	0.805	0.525	0.00081	0.99982
M1	0.755	0.00065	0.610	0.772	0.00127	0.99976
M2	0.781	0.00035	0.805	0.622	0.00101	0.99985
M2	0.781	0.00072	0.604	0.813	0.00154	0.99977
M3	0.796	0.00029	0.817	0.609	0.00099	0.99986
M3	0.796	0.00062	0.616	0.811	0.00155	0.99977
M4	0.803	0.00029	0.805	0.621	0.00101	0.99985
M4	0.803	0.00059	0.610	0.803	0.00147	0.99977

M1: current chronological age; M2: current chronological age + PhenoAgeAccel at baseline; M3: current chronological age + pre-existing diseases or conditions; M4: current chronological age + pre-existing diseases or conditions + PhenoAgeAccel at baseline; Threshold: predicted probability threshold; SEN: sensitivity; SPEC: specificity; PPV: Positive Predictive Value; NPV: Negative Predictive Value