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. 2020 Jul 1;31(14):1474–1485. doi: 10.1091/mbc.E20-01-0079

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© 2020 Natan et al. “ASCB®,” “The American Society for Cell Biology®,” and “Molecular Biology of the Cell®” are registered trademarks of The American Society for Cell Biology.

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FIGURE 5: — The effect of ARP2/3 inhibition on protrusion branching and band formation. Fibroblast cells (actin-GFP, green) were embedded in untreated fibrin gels (A) or treated with CK636, an inhibitor of ARP2/3, immediately after gel polymerization (B). The highly deformed matrix is indicated in gray isosurface. Two examples of cells from untreated and ARP2/3-inhibited gels are shown; white arrows indicate protrusion branching (C). Inhibition of ARP2/3 did not affect the average number of protrusions per cell, but decreased the number of protrusion branching per cell by ∼40% compared with cells in untreated gels. The number of bands per cell was reduced by about 60% in gels treated with ARP2/3 compared with cells in untreated gels (D). A statistically significant difference was observed between the number of protrusion branching and bands per cell, in comparison to control untreated samples. The values represent the mean ± SD of 100–200 analyzed cells. ** represents p values of chi-square analysis <0.005.