Table 2.
Quality Assessment of Included Cohort Studies Using the Newcastle-Ottawa Scale
| Author | Selection | Comparability | Outcome | |||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Representativeness of Exposed Cohort | Selection of Non-Exposed Cohort | Ascertainment of Exposure | Demonstration That Outcome of Interest Was Not Present at Start of Study | Adjust for fracture type | Adjust for other fracture risk factors | Assessment of outcome | Follow-up > 1 year | Loss to follow-up rate | Total Quality Score | |
| Lanzetti RM. 2018 [5] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 8 |
| Skala-Rosenbaum, 2010 [6] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 8 |
| Skala-Rosenbaum,2016 [7] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 7 |
| Vopat BG, 2014 [8] | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 1 | 1 | 7 |
| Yun, Ho Hyun, 2015 [9] | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 1 | 7 |
The quality of included studies was assessed by the Newcastle Ottawa scale. A study can be awarded a maximum of one star for each numbered item within the Selection and Outcome categories and a maximum of two stars for Comparability
Selection: 1) Representativeness of exposed cohort: 1, study population truly or somewhat representative of a community/ population based study; 0, study population was sampled from a special population, that is, population from a company, hospital patients, data from the health insurance company or health examination organization, nurses
2) Selection of non-exposed cohort: 1, drawn from the same community as the exposed cohort
3) Ascertainment of exposure: 1, Validation of macrolides use with secure medical record; 0, no specific macrolides use validation method
4) Demonstration that outcome was not present at start of study: 1, exclusion of participants with a history of severe ventricular arrhythmia or sudden cardiac arrest at the beginning of the study
Comparability: 1) 1, whether a study adjusted for fracture type deliberately; 1, whether a study adjusted for other risk factors
Outcome: 1) Assessment of outcome: 1, events were confirmed by medical records or record linkage; 0, self-reported
2) Was follow-up long enough for outcomes to occur: 1, duration of follow-up > = 1 year; 0, if duration of follow-up < 1 year
3) Loss to follow-up rate: 1, complete follow-up or loss to follow up rate < =20%; 0, follow-up rate < 80% or no description of those lost