Table 3.
Categorization according to clinical diagnosis and ATN biomarker profiles
| ATN profiles | EOAD | LOAD | MCI | SCD | PD | HC | N/αS+ (%) | ||
|---|---|---|---|---|---|---|---|---|---|
| A−T−N− | N/αS− | 1 | 4 | 5 | 8 | 34 | 27 | 5 | |
| N/αS+ | – | – | – | 3 | – | 1 | |||
| A+T−N− | N/αS− | 3 | 1 | 1 | – | 4 | – | 59 | |
| N/αS+ | 8 | 3 | – | – | 2 | – | |||
| AD | A+T+N− | N/αS− | 1 | – | – | – | – | – | 0 |
| N/αS+ | – | – | – | – | – | – | |||
| A+T+N+ | N/αS− | 2 | 1 | – | 1 | – | 1 | 92 | |
| N/αS+ | 41 | 17 | 2 | – | 1 | – | |||
| A+T−N+ | N/αS− | – | – | – | – | – | – | 100 | |
| N/αS+ | 10 | 5 | – | 1 | – | – | |||
| SNAP | A−T−N+ | N/αS− | – | 1 | – | 1 | 1 | – | 0 |
| N/αS+ | – | – | – | – | – | – | |||
| A−T+N− | N/αS− | – | – | 1 | 1 | 1 | 1 | 0 | |
| N/αS+ | – | – | – | – | – | – | |||
| A−T+N+ | N/αS- | – | 1 | 2 | 2 | 2 | 2 | 40 | |
| N/αS+ | 5 | 1 | – | – | – | – | |||
| N/αS+ (%) | 90 | 77 | 18 | 24 | 7 | 3 | |||
Abbreviations: AD Alzheimer’s disease, EOAD early-onset Alzheimer’s disease, LOAD late-onset Alzheimer’s disease, MCI mild cognitive impairment, SCD subjective cognitive decline, PD Parkinson’s disease, HC healthy control, SNAP suspected non-Alzheimer’s disease pathophysiology