Table 1.

DXA and pQCT analysis of Scl Ab treatment

DXA Whole Body Analysis	WT Veh (n = 11)	WT Scl Ab (n = 12)	TIEG KO Veh (n = 12)	TIEG KO Scl Ab (n = 12)	Treatment	Model	Interaction
Total Bone Mineral Density (g/cm2)	0.057 ± 0.002	0.063 ± 0.001	0.057 ± 0.002	0.060 ± 0.001	0.0041	NS	NS
Total Bone Mineral Content (g)	0.476 ± 0.019	0.550 ± 0.017	0.456 ± 0.020	0.506 ± 0.012	0.0005	NS	NS
pQCT Tibial Metaphysis Analysis
Total Content (mg)	1.45 ± 0.03	1.67 ± 0.04	1.37 ± 0.03	1.62 ± 0.02	<0.0001	0.0266	NS
Total Density (mg/cm3)	426 ± 9	500 ± 7	430 ± 6	506 ± 7	<0.0001	NS	NS
Trabecular Content (mg)	0.279 ± 0.008	0.239 ± 0.011	0.239 ± 0.011	0.230 ± 0.012	0.0105	0.0105	NS
Trabecular Density (mg/cm3)	201 ± 3	208 ± 4	190 ± 4	207 ± 4	NS	0.0054	NS
Trabecular Area (mm2)	1.40 ± 0.05	1.16 ± 0.04	1.25 ± 0.04	1.11 ± 0.04	0.0001	0.0334	NS
pQCT Tibial Diaphysis Analysis
Total Content (mg)	1.01 ± 0.03	1.13 ± 0.03	0.92 ± 0.01	1.06 ± 0.01	<0.0001	0.0002	NS
Total Density (mg/cm3)	734 ± 6	799 ± 7	736 ± 7	813 ± 7	NS	<0.0001	NS
Cortical Content (mg)	0.785 ± 0.020	0.906 ± 0.022	0.708 ± 0.014	0.853 ± 0.011	<0.0001	0.0005	NS
Cortical Density (mg/cm3)	1129 ± 5	1177 ± 5	1120 ± 5	1176 ± 4	<0.0001	NS	NS
Cortical Area (mm2)	0.696 ± 0.017	0.770 ± 0.017	0.631 ± 0.011	0.723 ± 0.009	<0.0001	0.0002	NS
Cortical Thickness (mm)	0.362 ± 0.009 (n=3)	0.404 ± 0.007 (n=8)	0.365 ± 0.004 (n=6)	0.401 ± 0.009 (n=7)	NS	NS	NS
Periosteal Circumference (mm)	4.16 ± 0.05	4.21 ± 0.05	3.96 ± 0.03	4.04 ± 0.03	NS	<0.0001	NS
Endosteal Circumference (mm)	2.93 ± 0.04	2.83 ± 0.04	2.78 ± 0.03	2.69 ± 0.03	<0.0001	<0.0001	<0.0001

Data expressed as mean ± SE. Two-way ANOVA reported as interaction. Significance in ANOVA for treatment or model are noted. Significance level p ≤ 0.05.