. Author manuscript; available in PMC: 2021 Jul 1.

Published in final edited form as: J Cell Physiol. 2020 Jan 24;235(7-8):5679–5688. doi: 10.1002/jcp.29500

Table 3.

MicroCT analysis of L3 Vertebra in mice following 6 weeks of vehicle (Veh) or sclerostin antibody (Scl Ab) treatment

Vertebra	WT Veh (n = 11)	TIEG KO Veh (n = 12)	WT Scl Ab (n = 12)	TIEG KO Scl Ab (n = 12)	Treatment	Model	Interaction
Bone volume (mm3)	4.81 ± 0.14	4.65 ± 0.16	6.05 ± 0.16	6.14 ± 0.09	<0.0001	0.6735	0.3882

3rd Lumbar vertebra

Bone Volume/Total Volume (%)	12.38 ± 0.34	12.69 ± 0.86	20.28 ± 0.86	21.04 ± 0.6	<0.0001	0.5994	0.5155
Connectivity Density (1/mm³)	130.76 ± 7.17	158.65 ± 15.69	151.35 ± 8.38	184.31 ± 8.45	0.0395	0.0071	0.5745
Trabecular Number (1/mm)	3.66 ± 0.06	3.85 ± 0.16	4.11 ± 0.12	4.17 ± 0.07	0.0011	0.3001	0.4747
Trabecular Thickness (μm)	41 ± 1	40 ± 1	53 ± 1	52 ± 1	<0.0001	0.1625	1
Trabecular Spacing (μm)	276 ± 5	268 ± 11	246 ± 8	241 ± 4	0.0004	0.4245	0.657

Data expressed as mean ± SE.