Table 2. Activity of Gomphoside Monoacetate (5g) and Uscharin (5z) in Mice Harboring a Chronic S. mansoni Infection.
| mean
number of worms |
||||||||
|---|---|---|---|---|---|---|---|---|
| liver |
||||||||
| no. | no. of mice cured/total | alive | dead | MV | total | males | females | total WBRa (%) |
| control | 0/8 | 0.3 ± 0.7 | 0 ± 0 | 22.4 ± 10.2 | 22.6 ± 9.9 | 11.4 ± 4.9 | 11.3 ± 4.9 | |
| 5z | 0/4 | 0.7 ± 1.1 | 0 ± 0 | 27.7 ± 6.5 | 28.3 ± 7.5 | 15.3 ± 3.2 | 13.0 ± 4.6 | 0 |
| 5g | 0/4b | 3.0 ± 4.2 | 5.7 ± 2.5 | 11.0 ± 7.1 | 14.0 ± 2.8 | 7.0 ± 1.4 | 7.0 ± 1.4 | 38.1 |
a
WBR = worm burden reduction.
b
One mouse was found dead three hours after application.