Table 1.
List of KEGG pathways analyzed by BioNSi (including 16 selected key genes).
| EGFR tyrosine kinase inhibitor resistance | AMPK signaling pathway | Insulin signaling pathway | p53 signaling pathway | Cell cycle | FoXO signaling pathway | PI3K-Akt signaling pathway | Apoptosis | Cellular senescence | |
|---|---|---|---|---|---|---|---|---|---|
| ATM | |||||||||
| SOD2 | |||||||||
| STAT3 | |||||||||
| CHEK2 | |||||||||
| TP53 | |||||||||
| IGF1R | |||||||||
| INSR | |||||||||
| AKT3 | |||||||||
| CCND1 | |||||||||
| CASP3 | |||||||||
| HRAS | |||||||||
| CDKN1A | |||||||||
| MTOR | |||||||||
| JAK1 | |||||||||
| PRKAA1 (AMPK) | |||||||||
| CDKN2A |
Nine pathways were selected for BioNSi network analysis [EGFR tyrosine kinase inhibitor resistance (hsa01521), AMPK signaling pathway (hsa04152), Insulin signaling pathway (hsa04910), P53 signaling pathway (hsa04115), Cell cycle (hsa04110), FoxO signaling pathway (hsa04068), PI3K-Akt signaling pathway (hsa04151), Apoptosis (hsa04210), cellular senescence (hsa04218)]. The 16 selected genes that participate in specific KEGG pathways (gray boxes) were tested by immunoblotting assays.