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. Author manuscript; available in PMC: 2020 Jul 14.
Published in final edited form as: J Am Chem Soc. 2020 Feb 4;142(7):3351–3355. doi: 10.1021/jacs.9b13405

Figure 2. Cross-competition kinetic experiment between two inhibitors.

Figure 2.

(a) TSA 17 and HPI 2 at [2] = 0 nM (●), 10 nM (●), 20 nM (●), and 40 nM (●). These two inhibitors do not compete, as lines converge near the x-axis. (b) TSA 17 and HPI-TSA 6 at [6] = 0 nM (●), 0.2 nM (●), 0.4 nM (●), and 0.8 nM (●). Parallel lines indicate cross-competition. (c) HPI 2 and HPI-TSA 6 at [6] = 0 nM (●), 0.2 nM (●), 0.4 nM (●), and 0.8 nM (●). Again, parallel lines indicate cross-competition, and HPI-TSA 6 competes with both TSA 17 and HPI 2.