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. Author manuscript; available in PMC: 2020 Jul 14.
Published in final edited form as: J Am Chem Soc. 2020 Feb 4;142(7):3351–3355. doi: 10.1021/jacs.9b13405

Figure 3: Competition of HPI-TSAs with photoaffinity probes for γ-secretase.

Figure 3:

Photoprobes TSA-Bpa-Bt (left) and HPI-Bpa-Bt (right) covalently label presenilin-1 (PS1) N-terminal fragment (NTF) at the active site and docking site, respectively. (a) TSA (17) but not HPI (2) decreased the labelling of PS1 NTF by the TSA photoprobe. (b) HPI (2) but not TSA (17) decreased the labelling PS1 NTF by the HPI photoprobe. (c, d). HPI-TSAs 6 and 16 decreased labelling by both TSA photoprobe (c) and HPI photoprobe (d).