TABLE 2.

Relationship of peripheral blood leukocytes telomere length to survival in critically ill patients across both Vanderbilt University Medical Center (VUMC) cohort and University of California San Francisco (UCSF) sepsis cohort using Cox proportional hazards models

	Telomere length per 1 kb decrease
	Subjects n	HR (95% CI)	p-value
VUMC critically ill cohort	937
90-day survival
Unadjusted		1.56 (1.32–1.83)	<0.0001
Adjusted#		1.30 (1.08–1.56)	0.004
1-year survival
Unadjusted		1.53 (1.33–1.78)	<0.0001
Adjusted#		1.27 (1.08–1.49)	0.004
VUMC sepsis subgroup	368
90-day survival
Unadjusted		1.61 (1.27–2.06)	<0.0001
Adjusted#		1.54 (1.19–2.00)	0.001
1-year survival
Unadjusted		1.51 (1.22–1.86)	0.0001
Adjusted#		1.41 (1.12–1.77)	0.003
UCSF sepsis cohort	394
60-day survival
Unadjusted		1.53 (1.19–1.98)	0.001
Adjusted#		1.57 (1.17–2.12)	0.003

HR: hazard ratio.

^#: adjusted for age, sex, ethnicity, smoking status, and Acute Physiology and Chronic Health Evaluation (APACHE) II score.