Table 1.
Analytic figures of merit for quality control samples bracketing cell and tissue levels of dNM/D/TPs.
| 1 ng/sample | 10 ng/sample | 100 ng/sample | 200 ng/sample | 600 ng/sample | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Analyte | M.W. | Internal Standard | Model | Precision (%CV) | AccuracY (%Bias) | Precision (%CV) | Accuracy (%Bias) | Precision (%CV) | Accuracy (%Bias) | Precision (%C V) | Accuracy (%8ias) | Precision (%CV) | Accuracy (%Bias) |
| dAMP | 331.22 | N/A | |||||||||||
| dADP | 411.20 | dATP | no weighting | 8% | 19% | 9% | -6% | 9% | 28% | ||||
| dATP | 491.18 | dATP | no weighting | 5% | 18% | 8% | −12% | 6% | 7% | ||||
| dTMP | 321.20 | dTTP | no weighting | 14% | 7% | 5% | 4% | 5% | 0% | ||||
| dTDP | 402.19 | dTTP | 1/x weighting | 13% | −18% | 6% | 3% | 23% | 9% | ||||
| dTTP | 482.17 | dTTP | 1/x weighting | 9% | 7% | 5% | −2% | 2% | 4% | ||||
| dCMP | 307.20 | dCMP | no weighting | 22% | −8% | 9% | 1% | 6% | 2% | 6% | 2% | ||
| dCOP | 387.18 | dCTP | no weighting | 3% | 8% | 17% | 7% | ||||||
| dCTP | 467.16 | dCTP | no weighting | 10% | −3% | 13% | 11% |