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. Author manuscript; available in PMC: 2021 Jun 1.
Published in final edited form as: Mol Oral Microbiol. 2020 Mar 10;35(3):85–105. doi: 10.1111/omi.12284

Figure 2. Structure of LFA-1. (A) LFA-1.

Figure 2.

LFA-1 is a heterodimeric integrin composed of CD11a and CD18 subunits. Both subunits contain short cytoplasmic domains, transmembrane domains, and large extracellular domains. (B) CD11a β-propeller. The CD11a β-propeller consists of seven sheets (W1–W7), each comprised of four strands (S1–S4). (C) Reported LtxA Binding Sites. LtxA has been reported to target the CD11a β-propeller, the CD18 I-EGF domains, and the cytoplasmic domains of both CD11a and CD18. Each reported binding site is highlighted in red.