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. 2020 Jul 7;11:742. doi: 10.3389/fphys.2020.00742

FIGURE 4.

FIGURE 4

The platelet-derived miR-223 suppressed VSMC proliferation via the regulation AMPK signaling pathways. VSMCs were transfected with miR-223 mimic for 48 h. (A,B) The phosphorylation of AMPKα and ACC were assessed by western blot analysis in VSMCs transfected with miR-223 mimic. (C,D) The expression of cell cycle marks including p27 and p21 was determined with western blot analysis in VSMCs transfected with miR-223 mimic. Data are presented as mean ± SD (n = 6). Comparisons between two groups were analyzed using unpaired nonparametric Student’s t-test. *P < 0.05, **P < 0.01, ***P < 0.001 vs Ctrl (miR-NC).