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. 2020 Mar 9;13(4):718–726. doi: 10.1111/cts.12757

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© 2020 The Authors. Clinical and Translational Science published by Wiley Periodicals, Inc. on behalf of the American Society for Clinical Pharmacology and Therapeutics.

This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.

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Correlation between international normalized ratio (INR) value with abundance of total prothrombin, carboxy peptide, and des‐carboxy peptides in serum samples from warfarin‐treated subjects. (a–d) represent correlations with INR in warfarin‐treated samples (group 1). (e,f) Represent the correlation between carboxy peptide ANTFL[E][E]VRK with des‐carboxy peptides GNLER and ANTFLEEVRK in the same sample set. INR values negatively correlated with carboxy peptides while positively correlated with des‐carboxy peptides. In addition, there was a strong negative correlation between carboxy peptide and des‐carboxy peptides.