Table 2.

Patients who developed dysarthria during CPT-11 infusion in our institution

Clinical cases	CPT-11 dose (regimens)	No. of cycles of CPT-11	Duration of CPT-11 infusion (min)	Pre-medication	Concurrent medication	Resolution of CNS symptoms	Prophylaxis medications for the following cycles
Patient 1	180 mg/mq (+ 5FU 1000 mg/mq g1 – > 2; FOLFIRI + Cetuximab)	2	90	Ondansetron 8 mg Dexamethasone 8 mg Atropine 0.25 mg	NA	Spontaneously	Atropine 0.5 mg
Patient 2	180 mg/mq (+ 5FU 1000 mg/mq g1 – > 2, FOLFIRI)	2	90	Ondansetron 12 mg Dexamethasone 10 mg Atropine 0.25 mg	Tramadol, ketorolac	Spontaneously	Atropine 0.25 mg
Patient 3	180 mg/mq (+ 5FU 1000 mg/mq g1 – > 2, FOLFIRI)	2	90	Ondansetron 8 mg Dexamethasone 8 mg Atropine 0.25 mg	NA	Spontaneously	Discontinued
Patient 4	180 mg/mq (+ 5FU 1000 mg/mq g1 – > 2, FOLFIRI)	2	90	Ondansetron 8 mg Dexamethasone 8 mg Atropine 0.25 mg	NA	Hydrocortisone 1 g Atropine 1 mg	Dexamethasone 16 mg Atropine 1 mg