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. 2018 Mar 15;6(1):9–20. doi: 10.1007/s40487-018-0058-6

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© The Author(s) 2018

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Fig. 1a–b — Normal protein translation involves tRNA with linked amino acids matching with the mRNA at the A site. The nascent peptide chain at the P site is then transferred to the incoming amino acid and the tRNA is moved to the P site to enable a new amino-acyl-tRNA to enter the A site (a), leading to further protein translation and protein production. Omacetaxine blocks the A site (b), thereby inhibiting protein synthesis