Table 2.

Symptom scores

Symptom	Treatment	V1 (mean ± SD)	V2 (mean ± SD)	V3 (mean ± SD)	V4 (mean ± SD)
Dry mucosa	Prophylactic ectoine	0.0 ± 0.0	0.2 ± 0.6	0.5 ± 0.8	0.5 ± 0.8
	Active ectoine	1.7 ± 0.6	1.4 ± 0.6	1.0 ± 0.7	0.4 ± 0.9
	Calcium phosphate	1.9 ± 0.5	1.7 ± 0.6	1.3 ± 0.5	0.6 ± 0.5
Mucosa irritation	Prophylactic ectoine	0.0 ± 0.0	0.0 ± 0.0	0.5 ± 0.8	0.5 ± 0.8
	Active ectoine	1.7 ± 1.7	1.4 ± 0.7	1.1 ± 0.9	0.3 ± 0.6
	Calcium phosphate	1.9 ± 0.5	1.6 ± 0.6	1.1 ± 0.4	0.6 ± 0.5
Coated tongue	Prophylactic ectoine	0.0 ± 0.0	0.2 ± 0.6	0.2 ± 0.6	0.0 ± 0.0
	Active ectoine	1.4 ± 0.9	1.1 ± 0.8	0.4 ± 0.9	0.3 ± 0.9
	Calcium phosphate	1.8 ± 0.6	1.6 ± 0.6	0.9 ± 0.5	0.4 ± 0.5
Unpleasant breath	Prophylactic ectoine	0.2 ± 0.4	0.0 ± 0.0	0.3 ± 0.9	0.2 ± 0.6
	Active ectoine	1.3 ± 0.7	0.9 ± 0.8	0.4 ± 0.6	0.1 ± 0.4
	Calcium phosphate	1.7 ± 0.6	1.5 ± 0.6	0.9 ± 0.8	0.4 ± 0.5
Decreased saliva production	Prophylactic ectoine	0.0 ± 0.0	0.2 ± 0.6	0.2 ± 0.6	0.3 ± 0.7
	Active ectoine	1.2 ± 0.7	0.8 ± 0.5	0.4 ± 0.9	0.3 ± 0.9
	Calcium phosphate	1.6 ± 0.6	1.5 ± 0.6	0.9 ± 0.6	0.3 ± 0.5
Pain	Prophylactic ectoine	0.0 ± 0.0	0.0 ± 0.0	0.6 ± 0.7	0.6 ± 0.7
	Active ectoine	1.7 ± 0.6	1.2 ± 0.7	0.6 ± 1.1	0.3 ± 0.6
	Calcium phosphate	1.6 ± 0.8	1.2 ± 0.8	0.9 ± 0.8	0.3 ± 0.5
Swelling	Prophylactic ectoine	0.0 ± 0.0	0.0 ± 0.0	0.1 ± 0.3	0.0 ± 0.0
	Active ectoine	0.4 ± 0.8	0.3 ± 0.6	0.2 ± 0.6	0.1 ± 0.5
	Calcium phosphate	0.6 ± 0.8	0.5 ± 0.6	0.1 ± 0.4	0.1 ± 0.3
Ulcer	Prophylactic ectoine	0.0 ± 0.0	0.0 ± 0.0	0.0 ± 0.0	0.0 ± 0.0
	Active ectoine	0.6 ± 0.8	0.6 ± 1.0	0.2 ± 0.6	0.1 ± 0.4
	Calcium phosphate	1.1 ± 1.1	0.7 ± 0.8	0.3 ± 0.6	0.1 ± 0.3
Difficulties speaking	Prophylactic ectoine	0.0 ± 0.0	0.0 ± 0.0	0.0 ± 0.0	0.1 ± 0.3
	Active ectoine	0.2 ± 0.8	0.2 ± 0.6	0.2 ± 0.6	0.1 ± 0.5
	Calcium phosphate	0.2 ± 0.8	0.2 ± 0.8	0.0 ± 0.0	0.0 ± 0.0
Difficulties eating/drinking	Prophylactic ectoine	0.0 ± 0.0	0.0 ± 0.0	0.6 ± 0.8	0.9 ± 0.7
	Active ectoine	0.6 ± 1.1	0.6 ± 1.1	0.4 ± 1.1	0.3 ± 0.7
	Calcium phosphate	0.3 ± 0.8	0.3 ± 0.8	0.1 ± 0.3	0.1 ± 0.3