Table 1.
Events/total | Hazard ratio (95% CI) | P-valueb | |
---|---|---|---|
Age, 5-year increase | 1428/1987 | 1.04 (1.01–1.07) | 0.0057 |
Gender | |||
Female | 614/860 | 0.88 (0.79–0.98) | 0.0218 |
Male | 814/1127 | Reference | |
Primary tumor location | |||
Distal | 657/1026 | 0.64 (0.57–0.72) | <0.0001 |
Proximal | 771/961 | Reference | |
T-stage | |||
T1/2 | 60/104 | Reference | |
T3 | 1048/1469 | 1.20 (0.92–1.57) | 0.1746 |
T4 | 320/414 | 1.45 (1.09–1.92) | 0.0102 |
N-Stage | |||
N1 | 583/890 | Reference | |
N2 | 845/1097 | 1.36 (1.22–1.51) | <0.0001 |
Histologic grade | |||
Low grade (grade 1–2) | 1022/1482 | Reference | |
High grade (grade 3/4) | 406/505 | 1.36 (1.20–1.53) | <0.0001 |
KRAS status | |||
MT | 597/791 | 1.21 (1.07–1.36) | 0.0023 |
WT | 831/1196 | Reference | |
Performance score | |||
0 | 1077/1519 | Reference | |
1 | 341/457 | 1.18 (1.04–1.34) | 0.0089 |
2 | 10/11 | 3.54 (1.87–6.70) | 0.0001 |
Time-to-recurrence, 1-year increase | 1428/1987 | 0.87 (0.82–0.91) | <0.0001 |
MSI, microsatellite instable; MMR, mismatch repair; BRAF; CI, confidence interval; KRAS; MT, mutated; WT, wild type.
A single multivariable Cox model was fitted with variables listed in the table, plus MSI/MMR and BRAF variables. The HRs associated with MSI/MMR and BRAF are reported in Table 2 (first two sections).
Stratified covariate Wald P-value.