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. 2019 Dec 12;30(9):1466–1471. doi: 10.1093/annonc/mdz208

Table 1.

Multivariable associations between patient demographics and disease characteristics with survival after recurrence (SAR), adjusting for biomarkers (MSI/MMR and BRAF)a

Events/total Hazard ratio (95% CI) P-valueb
Age, 5-year increase 1428/1987 1.04 (1.01–1.07) 0.0057
Gender
 Female 614/860 0.88 (0.79–0.98) 0.0218
 Male 814/1127 Reference
Primary tumor location
 Distal 657/1026 0.64 (0.57–0.72) <0.0001
 Proximal 771/961 Reference
T-stage
 T1/2 60/104 Reference
 T3 1048/1469 1.20 (0.92–1.57) 0.1746
 T4 320/414 1.45 (1.09–1.92) 0.0102
N-Stage
 N1 583/890 Reference
 N2 845/1097 1.36 (1.22–1.51) <0.0001
Histologic grade
 Low grade (grade 1–2) 1022/1482 Reference
 High grade (grade 3/4) 406/505 1.36 (1.20–1.53) <0.0001
KRAS status
 MT 597/791 1.21 (1.07–1.36) 0.0023
 WT 831/1196 Reference
Performance score
 0 1077/1519 Reference
 1 341/457 1.18 (1.04–1.34) 0.0089
 2 10/11 3.54 (1.87–6.70) 0.0001
Time-to-recurrence, 1-year increase 1428/1987 0.87 (0.82–0.91) <0.0001

MSI, microsatellite instable; MMR, mismatch repair; BRAF; CI, confidence interval; KRAS; MT, mutated; WT, wild type.

a

A single multivariable Cox model was fitted with variables listed in the table, plus MSI/MMR and BRAF variables. The HRs associated with MSI/MMR and BRAF are reported in Table 2 (first two sections).

b

Stratified covariate Wald P-value.