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Categories of acute and chronic graft-versus-host disease
| Category | Time of symptoms after HCT or DLI | Presence of acute GVHD features | Presence of chronic GVHD features |
|---|---|---|---|
| Acute GVHD | |||
| Classic | ≤ 100 days | Yes | No |
| Persistent, recurrent, or late-onset | ≥ 100 days | Yes | No |
| Chronic GVHD | |||
| Classic | No time limit | No | Yes |
| Overlap syndrome | No time limit | Yes | Yes |
Adapted from Filipovich et al.9
DLI, Donor lymphocyte infusion; GVHD, graft-versus-host disease; HCT, hematopoietic cell transplant.
