Table IV.

Comparison of sclerotic-type chronic graft-versus-host disease and systemic sclerosis

	Sclerotic-type chronic GVHD	Systemic sclerosis
Autoantibodies	Variable, nonspecific	Yes, associated with specific clinical subtypes
Cardiac involvement	Rare	Yes, conduction system abnormalities
Gastrointestinal dysmotility/strictures	Yes	Yes
Pulmonary hypertension	No	Yes
Pulmonary fibrosis	Yes*	Yes
Renal disease	Rare, nephrotic syndrome	Yes, scleroderma renal crises (in diffuse subtype)
Raynaud disease	Rare	Yes
Sclerodactyly Skin manifestations	Rare	Yes
Fibrosis	Dermis, subcutaneous tissue, and/or fascia	Dermis
Natural history	Patchy involvement, variable course	Symmetric, acral to proximal progression
Facial involvement	Rare, usually patchy involvement	Common, diffuse skin tightening (scleroderma facies)

GVHD, Graft-versus-host disease.

^*In the setting of bronchiolitis obliterans.